JF669, SE

Names

[ CAS No. ]:
2127150-20-1

[ Name ]:
JF669, SE

Biological Activity

[Description]:

JF669, SE, a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669−HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm)[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

JF669 undergoes rapid conversion to thioether product (<5 min to completion) in organic solvents, where the dye predominantly adopts the closed form[1]. JF669 displays comparatively excellent photostability, retaining 97% fluorescence after the same number of cycles[1].

[References]

[1]. Jonathan B Grimm, et al. General Synthetic Method for Si-Fluoresceins and Si-Rhodamines. ACS Cent Sci. 2017 Sep 27;3(9):975-985.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H30F3N3O6SSi

[ Molecular Weight ]:
693.76

Related Compounds