Viminol

Names

[ Name ]:
Viminol

[Synonym ]:
1-[1-(2-chloro-benzyl)-pyrrol-2-yl]-2-(di-sec-butyl-amino)-ethanol
Viminol
Viminol [INN]
Viminolo [DCIT]
Diviminol
EINECS 244-347-8
Viminolo [Italian]
Viminolum [INN-Latin]

Biological Activity

[Description]:

Viminol is a centrally acting analgesic agent. Viminol also shows antitussive activity[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[References]

[1]. D Chiarino, et al. Stereochemistry of viminol, a novel central analgesic. Arzneimittelforschung. 1978;28(9):1554-61.

[2]. G Sabot, et al. Controlled evaluation of the antitussive activity of viminol p-hydroxybenzoate. Int J Clin Pharmacol Biopharm. 1977 Apr;15(4):181-3.

Chemical & Physical Properties

[ Density]:
1.07g/cm3

[ Boiling Point ]:
321.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₃₁ClN₂O

[ Molecular Weight ]:
362.94

[ Flash Point ]:
148.1ºC

[ Exact Mass ]:
362.21200

[ PSA ]:
28.40000

[ LogP ]:
5.12220

[ Vapour Pressure ]:
0.000125mmHg at 25°C

[ Index of Refraction ]:
1.544

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9635500

CHEMICAL NAME :: Pyrrole-2-methanol, 1-(o-chlorobenzyl)-alpha-((di-sec-butylamino)methyl)-

CAS REGISTRY NUMBER :: 21363-18-8

BEILSTEIN REFERENCE NO. :: 0444219

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H31-Cl-N2-O

MOLECULAR WEIGHT :: 362.99

WISWESSER LINE NOTATION :: T5NJ A1R BG& BYQ1NY2&1&Y2&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,5,1972