LSD1-IN-13
Names
[ CAS No. ]:
2170212-33-4
[ Name ]:
LSD1-IN-13
Biological Activity
[Description]:
LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines[1].
[Related Catalog]:
[Target]
IC50: 24.43 ± 1.08 nM (LSD1), 5.00 ± 0.28 μM (LSD2), >100 μM (MAO-A), >100 μM (MAO-B)[1]
[In Vitro]
LSD1-IN-13 (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold)[1]. LSD1-IN-13 shows potent and selective antiproliferative activity in MV-4-11, with an IC50 of 1.36 μM[1].
[In Vivo]
LSD1-IN-13 (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H29N3O2S
[ Molecular Weight ]:
411.56