KRAS inhibitor-17

Names

[ CAS No. ]:
2230873-65-9

[ Name ]:
KRAS inhibitor-17

Biological Activity

[Description]:

KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:3.37 μM (IC50)


[References]

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Chemical & Physical Properties

[ Molecular Formula ]:
C21H18Cl2FN3O2S

[ Molecular Weight ]:
466.36

Related Compounds