KRAS inhibitor-16

Names

[ CAS No. ]:
2230873-67-1

[ Name ]:
KRAS inhibitor-16

Biological Activity

[Description]:

KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:0.457 μM (IC50)


[References]

[1]. Brian Alan LANMAN, et al. Kras g12c inhibitors and methods of using the same. US20180334454A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H16Cl2FN3O2S

[ Molecular Weight ]:
452.33

Related Compounds