KRAS inhibitor-14

Names

[ CAS No. ]:
2230873-78-4

[ Name ]:
KRAS inhibitor-14

Biological Activity

[Description]:

KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:0.249 μM (IC50)


[References]

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Chemical & Physical Properties

[ Molecular Formula ]:
C20H15Cl3FN3O2S

[ Molecular Weight ]:
486.77

Related Compounds