Axl-IN-8

Names

[ CAS No. ]:
2231424-62-5

[ Name ]:
Axl-IN-8

Biological Activity

[Description]:

Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of <1 nM. Axl-IN-8 also inhibits c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of <10, 226.6 and 120.3 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[Target]

c-Met:1-10 nM (IC50)


[References]

[1]. Duan Wenhu, et al. Compound having axl inhibitory activity, preparation method therefor and use thereof. WO2018121228A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H29FN6O3

[ Molecular Weight ]:
552.60

Related Compounds