tert-Butyl ((17-amino-3,6,9,12,15-pentaoxaheptadecyl)oxy)carbamate

Names

[ CAS No. ]:
2250216-94-3

[ Name ]:
tert-Butyl ((17-amino-3,6,9,12,15-pentaoxaheptadecyl)oxy)carbamate

Biological Activity

[Description]:

Boc-Aminooxy-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₃₆N₂O₈

[ Molecular Weight ]:
396.48