STING agonist-11

Names

[ CAS No. ]:
2259308-68-2

[ Name ]:
STING agonist-11

Biological Activity

[Description]:

STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC50 of 18 nM. Activation of STING is a highly promising approach in immunotherapy[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> STING

[References]

[1]. Sourav Basu, et al. The discovery of potent small molecule cyclic urea activators of STING. Eur J Med Chem. 2022 Feb 5;229:114087.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H20ClF4N3O2

[ Molecular Weight ]:
505.89

Related Compounds