SHP2 inhibitor LY6

Names

[ CAS No. ]:
2296718-09-5

[ Name ]:
SHP2 inhibitor LY6

Biological Activity

[Description]:

SHP2 inhibitor LY6 (LY6) is potent and selective inhibitor of SHP2, with an IC50 of 9.8 µM. SHP2 inhibitor LY6 can inhibits SHP2-mediated cell signaling and proliferation[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

IC50: 9.8 µM (SHP2)[1]


[References]

[1]. Wu X, et, al. Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2. J Med Chem. 2019 Feb 14;62(3):1125-1137.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H27Cl2N3O4

[ Molecular Weight ]:
564.46

Related Compounds