CXCR4 antagonist 8

Names

[ CAS No. ]:
2304750-84-1

[ Name ]:
CXCR4 antagonist 8

Biological Activity

[Description]:

CXCR4 antagonist 8 (Compound 3) is a CXCR4 antagonist with an IC50 of 57 nM. CXCR4 antagonist 8 inhibits CXCL12 induced cytosolic calcium increase with an IC50 of 0.24 nM. CXCR4 antagonist 8 inhibits CXLC12/CXCR4 mediated cell migration[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> GPCR/G Protein >> CXCR
Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4:57 nM (IC50)


[References]

[1]. Lin Y, et al. Design, synthesis, and evaluation of novel CXCR4 antagonists based on an aminoquinoline template. Bioorg Chem. 2020 Jun;99:103824.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H26N6

[ Molecular Weight ]:
362.47

Related Compounds