STING modulator-5

Names

[ CAS No. ]:
2305940-22-9

[ Name ]:
STING modulator-5

Biological Activity

[Description]:

STING modulator-5 (compound 38) is a STING modulator with a pIC50 value of 9.5. STING modulator-5 antagonizes peripheral blood mononuclear cells (PBMC) with a pIC50 value of 8.1. STING modulator-5 is a antagonist of THP-1 cells, it can be used for immunological disease research[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> STING

[In Vitro]

STING modulator-5 (4小时) 对外周血单核细胞 (PBMC) 有拮抗作用，pIC50 值为 8.1[1]。 STING modulator-5 对人 STING 的 C 端结构域 (CTD) 具有结合效力，通过 FRET 检测的 pIC50 值为 9.5[1]。 STING modulator-5 拮抗 THP-1 细胞的 pIC50 值为 8.9[1]。

[References]

[1]. Fosbenner, David T, et al. Modulators of stimulator of interferon genes. WO 2019/069270 Al. 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C43H45F4N11O5

[ Molecular Weight ]:
871.88

Related Compounds