BRM/BRG1 ATP Inhibitor-3

BRM/BRG1 ATP Inhibitor-3 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-3 inhibits BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively. BRM/BRG1 ATP Inhibitor-3 can be used for the research of cancers and BAF complex-related disorders[1].

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

IC50: 10.4 nM (BRM); 19.3 nM (BRG1)[1].

BRM/BRG1 ATP Inhibitor-3 has inhibitory activity for BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively[1]. BRM/BRG1 ATP Inhibitor-3 (0.01-10 μM) has inhibition for cell proliferation in several cancer cell lines[1]. Cell Proliferation Assay[1] Cell Line: Uveal melanoma cell lines (92-1 , MP41 , MP38, MP46), prostate cancer cell lines (LNCAP), lung cancer cell lines (NCI-H1299), and immortalized embryonic kidney lines (HEK293T) Concentration: 0-10 μM Incubation Time: 3 days Result: Inhibited cell proliferation of uveal melanoma cell line 92-1 and MP41.

[1]. Kevin J. Wilson, et al. Compounds and uses thereof. Patent. WO2021155320A1.