Nrf2 activator-4

Names

[ CAS No. ]:
2383016-68-8

[ Name ]:
Nrf2 activator-4

Biological Activity

[Description]:

Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[Target]

EC50: 0.63 µM (Nrf2)[1]


[References]

[1]. Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H24ClF3N2O3

[ Molecular Weight ]:
468.90

Related Compounds