Axl/Mer/CSF1R-IN-1

Names

[ CAS No. ]:
2394874-60-1

[ Name ]:
Axl/Mer/CSF1R-IN-1

Biological Activity

[Description]:

Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R inhibitor with Kds of <0.1 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms

[Target]

Kd: <0.1 μM (Axl, Mer, CSF1R)[1]


[In Vitro]

Axl/Mer-IN-1 (Compound 1) 抑制细胞 Axl 活性，通过 H1299 Elisa 法测得的IC50 为 <0.5 μM。Axl/Mer-IN-1 抑制细胞 CSF1R 活性，通过 THP-1 Elisa 法和 M-NFS-60 活力法测得的 IC50 分别为 <0.5 μM 和 <1.0 μM[1]。

[References]

[1]. Kiyean NAM, et al. Quinoline derivatives as inhibitors of axl/mer rtk and csf1r. Patent WO2019229251A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H24F3N5O5

[ Molecular Weight ]:
531.48

Related Compounds