ITK inhibitor 5

Names

[ CAS No. ]:
2404603-41-2

[ Name ]:
ITK inhibitor 5

Biological Activity

[Description]:

ITK inhibitor 5 (compound 27) is a potent and selective ITK inhibitor with IC50s of 5.6, 25 nM for ITK, BTK, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk

[References]

[1]. Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK). Eur J Med Chem. 2020 Feb 1;187:111918.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H18F2N4O2

[ Molecular Weight ]:
396.39

Related Compounds