STING agonist-24
Names
[ CAS No. ]:
2408722-91-6
[ Name ]:
STING agonist-24
Biological Activity
[Description]:
STING agonist-24 (CF504) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].
[Related Catalog]:
[In Vitro]
STING agonist-24 (10 μM;3 小时或 5 小时) 处理 THP-1 细胞 3 小时后,增加磷酸化 STING、TBK1 和 IRF3 的水平;处理 THP-1 细胞 5 小时后,增加 IFN-β、IL-6、CXCL-10、TNF-α、ISG-15 和 CCL-5 的含量[1]。
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C34H37N13O5
[ Molecular Weight ]:
707.74