Anti-inflammatory agent 21

Names

[ CAS No. ]:
2408836-40-6

[ Name ]:
Anti-inflammatory agent 21

Biological Activity

[Description]:

Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.76 μM (NO)[1]


[References]

[1]. Chen LZ, Wu J, Li K, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020;206:112722.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H21FO6

[ Molecular Weight ]:
424.42

Related Compounds