SARS 3CLpro-IN-1

Names

[ CAS No. ]:
2409178-86-3

[ Name ]:
SARS 3CLpro-IN-1

Biological Activity

[Description]:

SARS 3CLpro-IN-1 (Compound 3b) is a SARS 3CL protease inhibitor with an IC50 value of 95 μM, as a specific stereo isomerof the octahydroisochromene scaffold, directs the P1 site imidazole[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 95 μM (SARS 3CL protease) [1]


[In Vitro]

SARS 3CLpro-IN-1 (Compound 3b) has high active (IC50=95 μM) and had a (1S, 3S)-configuration in the ring system[1].

[References]

[1]. Shin-Ichiro Yoshizawa, et al. Evaluation of an octahydroisochromene scaffold used as a novel SARS 3CL protease inhibitor. Bioorg Med Chem. 2020 Feb 15;28(4):115273.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H38N4O2

[ Molecular Weight ]:
390.56

Related Compounds