5-HT6/5-HT2A receptor ligand-2

Names

[ CAS No. ]:
2411088-16-7

[ Name ]:
5-HT6/5-HT2A receptor ligand-2

Biological Activity

[Description]:

5-HT6/5-HT2A receptor ligand-2 (compound 42) is a brain-penetrant dual 5-HT6/5-HT2A receptor antagonist, with a Ki of 25 nM and 32 nM, respectively. 5-HT6/5-HT2A receptor ligand-2 shows pro-cognitive properties[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT6 Receptor:25 nM (Ki)

5-HT2A Receptor:32 nM (Ki)


[References]

[1]. Staroń J, et, al. Virtual screening-driven discovery of dual 5-HT 6/5-HT 2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 2020 Jan 1;185:111857.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H18FN3O2

[ Molecular Weight ]:
351.37

Related Compounds