Melatonin receptor agonist 1

Names

[ CAS No. ]:
2411150-76-8

[ Name ]:
Melatonin receptor agonist 1

Biological Activity

[Description]:

Melatonin receptor agonist 1 (compound 20c) is a potent melatonin receptor (MT) agonist, with Ki values of 108 nM (MT2) and 1140 nM (MT1)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor
Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor
Research Areas >> Neurological Disease

[Target]

MT2:108 nM (Ki)

MT1:1140 nM (Ki)


[In Vitro]

Melatonin receptor agonist 1 (compound 20c) shows a 10 times MT2-selectivity over MT1[1].

[References]

[1]. Bolteau R, et al. Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine. Eur J Med Chem. 2020 Mar 1;189:112078.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H19N3O2

[ Molecular Weight ]:
273.33

Related Compounds