VEGFR-2-IN-23

Names

[ CAS No. ]:
2411174-53-1

[ Name ]:
VEGFR-2-IN-23

Biological Activity

[Description]:

VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> MDM-2/p53
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR-2:0.19 nM (IC50)


[In Vitro]

VEGFR-2-IN-23 (compound 11b) shows antitumor activity with IC50s of 23, 0.8, 1.3, 46 nM for PC3, DU145, MCF-7, MDA-MB435 cells, respectively[1].

[In Vivo]

VEGFR-2-IN-23 (5, 10 mg/kg; i.p.) shows inhibits the tumor growth in MCF-7 xenograft tumor models[1].

[References]

[1]. AbdelHaleem A, et al. Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling. Bioorg Chem. 2020 Oct;103:104222.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H15N5O2

[ Molecular Weight ]:
381.39

Related Compounds