COX-2-IN-17

Names

[ CAS No. ]:
2411390-10-6

[ Name ]:
COX-2-IN-17

Biological Activity

[Description]:

COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2:0.02 μM (IC50)

COX-1:>10 μM (IC50)


[References]

[1]. Kumari P, et al. Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats. Bioorg Med Chem. 2020 Jan 15;28(2):115246.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23ClN6O2

[ Molecular Weight ]:
414.89

Related Compounds