LXRβ agonist-3
Names
[ CAS No. ]:
2413308-63-9
[ Name ]:
LXRβ agonist-3
Biological Activity
[Description]:
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma[1].
[Related Catalog]:
[Target]
EC50: 0.095 ± 0.012 μM (LXRβ) 0.277 ± 0.066 μM (LXRα)[1]
[In Vivo]
LXRβ agonist-3 (compound 4-13) (BALB/c mice, 50 mg/kg, IP, daily for 15 days) significantly reduces glioblastoma tumor growth[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C30H33N3O6S
[ Molecular Weight ]:
563.66