COX-2/15-LOX-IN-1

Names

[ CAS No. ]:
2413565-15-6

[ Name ]:
COX-2/15-LOX-IN-1

Biological Activity

[Description]:

COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX
Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

COX-1:10.65 μM (IC50)

COX-2:0.075 μM (IC50)

15-LOX:2.98 μM (IC50)


[References]

[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H21N7S3

[ Molecular Weight ]:
467.63

Related Compounds