COX-2-IN-27

Names

[ CAS No. ]:
2413565-17-8

[ Name ]:
COX-2-IN-27

Biological Activity

[Description]:

COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:13.22 μM (IC50)

COX-2:0.045 μM (IC50)

15-LOX:1.67 μM (IC50)


[In Vitro]

COX-2-IN-27 (compound 15b) shows significant COX-2 selectivity with an SI value of 293.78[1].

[In Vivo]

COX-2-IN-27 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 93.20% and 109.08% in 4h and 3h, respectively[1].

[References]

[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H24ClN7S3

[ Molecular Weight ]:
602.20

Related Compounds