COX-2-IN-28

Names

[ CAS No. ]:
2413565-18-9

[ Name ]:
COX-2-IN-28

Biological Activity

[Description]:

COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:13.21 μM (IC50)

COX-2:0.054 μM (IC50)

15-LOX:2.14 μM (IC50)


[In Vitro]

COX-2-IN-28 (compound 15c) shows significant COX-2 selectivity with an SI value of 244.63[1].

[References]

[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H27N7S3

[ Molecular Weight ]:
581.78

Related Compounds