Mt KARI-IN-2

Names

[ CAS No. ]:
2413974-52-2

[ Name ]:
Mt KARI-IN-2

Biological Activity

[Description]:

Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Ki: 2.02 μM (Mtb KARI)[1]


[References]

[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H11N5O4S2

[ Molecular Weight ]:
377.40

Related Compounds