Mt KARI-IN-5

Names

[ CAS No. ]:
2413974-69-1

[ Name ]:
Mt KARI-IN-5

Biological Activity

[Description]:

Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL)[1]

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Ki: 4.72 μM (Mtb KARI)[1]


[References]

[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H10N4O5S3

[ Molecular Weight ]:
410.45

Related Compounds