MMP-2/9-IN-1

Names

[ CAS No. ]:
2415311-84-9

[ Name ]:
MMP-2/9-IN-1

Biological Activity

[Description]:

MMP-2/9-IN-1 (Compound 4a) is a potent dual MMP-2 and MMP-9 inhibitor with IC50 values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-2:56 nM (IC50)

MMP-9:38 nM (IC50)


[References]

[1]. Omar AM, et al. Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects. Bioorg Chem. 2020 Aug;101:103992.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H16IN7S

[ Molecular Weight ]:
441.29

Related Compounds