EGFR-IN-64

Names

[ CAS No. ]:
2416924-93-9

[ Name ]:
EGFR-IN-64

Biological Activity

[Description]:

EGFR-IN-64 (Compound 3c) is a potent EGFR inhibitor with an IC50 of 0.33 μM. EGFR-IN-64 shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:0.33 μM (IC50)


[In Vitro]

EGFR-IN-64 (Compound 3c) shows cytotoxicity with IC50 values of 4.46 ± 0.11 μM and 16.23 ± 0.65 μM against MCF-7 and WI-38, respectively[1].

[References]

[1]. George RF, et al. Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking. Bioorg Chem. 2020 Jun;99:103780.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H21N3O3

[ Molecular Weight ]:
351.40

Related Compounds