COX-2-IN-23

Names

[ CAS No. ]:
2417995-08-3

[ Name ]:
COX-2-IN-23

Biological Activity

[Description]:

COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2:0.28 μM (IC50)

COX-1:20.14 μM (IC50)


[In Vivo]

COX-2-IN-23 (compound 9a) (9 mg/kg; a single i.p.; 0-4 hours) exhibits anti-inflammatory activities and lowest incidence of pepticulcer[1]. Animal Model: Mature male albino rats[1] Dosage: 9 mg/kg Administration: Intraperitoneal injection; 0, 1, 2, 3 and 4 hours. Result: Had similar ulcerogenic activity to celecoxib.

[References]

[1]. Ibrahim TS, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg Chem. 2020 Jul;100:103878.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25N5O3S2

[ Molecular Weight ]:
495.62

Related Compounds