COX-2-IN-24
Names
[ CAS No. ]:
2417995-10-7
[ Name ]:
COX-2-IN-24
Biological Activity
[Description]:
COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.
[Related Catalog]:
[Target]
COX-2:0.17 μM (IC50)
[In Vivo]
COX-2-IN-24 (Intraperitoneal injection; 9mg/100g; once an hour; 4 hours) shows anti-inflammatory activity in the carrageenan-induced rat paw edema model[1]. COX-2-IN-24 (Oral gavage; 9mg/100g; once a day; 3 days) shows low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model [1]. Animal Model: Mature male albino rats[1] Dosage: 9mg/100g Administration: Intraperitoneal injection; 9mg/100g; once an hour; 4 hours Result: Exhibited a promising anti-inflammatory activity in the carrageenan-induced rat paw edema model. Animal Model: Mature male albino rats[1] Dosage: 9mg/100g Administration: Oral gavage; 9mg/100g; once a day; 3 days Result: Exhibited low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C24H24BrN5O3S2
[ Molecular Weight ]:
574.51