ALR1/2-IN-1

Names

[ CAS No. ]:
2419233-57-9

[ Name ]:
ALR1/2-IN-1

Biological Activity

[Description]:

ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase

[Target]

IC50: 3.06 μM (ALR2), 3.26 μM (ALR1)[1]


[In Vitro]

ALR1/2-IN-1 (Compound 6e) (100 µM) shows cytotoxic potential with 32.9 ± 3.26% inhibition against cervical carcinoma cells HeLa[1].

[References]

[1]. Javid N, et al. Exploiting oxadiazole-sulfonamide hybrids as new structural leads to combat diabetic complications via aldose reductase inhibition. Bioorg Chem. 2020 Jun;99:103852.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H18N4O5S2

[ Molecular Weight ]:
434.49

Related Compounds