COX-2-IN-14

Names

[ CAS No. ]:
2428387-48-6

[ Name ]:
COX-2-IN-14

Biological Activity

[Description]:

COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2


[References]

[1]. Gonçalves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H18N4O6

[ Molecular Weight ]:
386.36

Related Compounds