VEGFR-2-IN-26

Names

[ CAS No. ]:
2439096-06-5

[ Name ]:
VEGFR-2-IN-26

Biological Activity

[Description]:

VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR-2:15.5 nM (IC50)


[References]

[1]. Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H19F3N6O2

[ Molecular Weight ]:
480.44

Related Compounds