GPR40 agonist 5

Names

[ CAS No. ]:
2443384-60-7

[ Name ]:
GPR40 agonist 5

Biological Activity

[Description]:

GPR40 agonist 5 (compound I-14) is an orally active and potent GPR40 (G protein coupled receptor 40) agonist, with an EC50 of 47 nM. GPR40 agonist 5 decreases the levels of blood glucose and improves the glucose tolerance. GPR40 agonist 5 has sufficient effectiveness for the control of hyperglycemia state in type 2 diabetic mice[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR40
Research Areas >> Metabolic Disease

[Target]

EC50: 47 ± 9.8 nM (GPR40)[1]


[References]

[1]. Ye Z, et al. Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents. Bioorg Med Chem. 2020 Jul 1;28(13):115574.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H24N2O4

[ Molecular Weight ]:
440.49

Related Compounds