FGFR3-IN-5

Names

[ CAS No. ]:
2446664-72-6

[ Name ]:
FGFR3-IN-5

Biological Activity

[Description]:

FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR3:3 nM (IC50)

FGFR2:44 nM (IC50)

FGFR1:289 nM (IC50)


[In Vitro]

FGFR3-IN-5 (compound 37; 5 mM; 1 h; HEK-293 细胞) 抑制 FGFR 磷酸化，对 FGFR3 和 FGFR1 的 IC50 值分别为8 nM 和 59 nM[1]。

[References]

[1]. James FB, et, al. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases. WO2020131627.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24FN7O3

[ Molecular Weight ]:
477.49

Related Compounds