hCAIX-IN-6

Names

[ CAS No. ]:
2451479-86-8

[ Name ]:
hCAIX-IN-6

Biological Activity

[Description]:

Compounds 6B and 14g showed significant inhibitory effect on tumor related subtype HCA IX with low nanomolar potency, while 6K was effective on HCA XII. Compounds 6B, 14g and 6K can be considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[References]

[1]. Swain B,et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H12N2O4S

[ Molecular Weight ]:
352.36

Related Compounds