PCSK9 modulator-3

Names

[ CAS No. ]:
2476490-18-1

[ Name ]:
PCSK9 modulator-3

Biological Activity

[Description]:

PCSK9 modulator-3 (Compound 13) is a potent modulator of PCSK9 with an EC50 value of 2.46 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-3 has the potential for the research of hyperlipidemia[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H9F2N3O

[ Molecular Weight ]:
297.26

Related Compounds