MPO-IN-5

Names

[ CAS No. ]:
2476764-11-9

[ Name ]:
MPO-IN-5

Biological Activity

[Description]:

MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO)[1]


[References]

[1]. Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24N6O2

[ Molecular Weight ]:
428.49

Related Compounds