EGFR-IN-56

Names

[ CAS No. ]:
2477726-83-1

[ Name ]:
EGFR-IN-56

Biological Activity

[Description]:

EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFRT790M:541.7 nM (IC50)

EGFRL858R/T790M:132.1 nM (IC50)


[References]

[1]. Xiao Z, et al. Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115669.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H22N4O3S

[ Molecular Weight ]:
434.51

Related Compounds