COX-2/5-LOX-IN-3

Names

[ CAS No. ]:
2481484-51-7

[ Name ]:
COX-2/5-LOX-IN-3

Biological Activity

[Description]:

COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX
Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

COX-2:5.45 μM (IC50)

COX-1:45.73 μM (IC50)

5-LOX:4.33 μM (IC50)


[In Vivo]

COX-2/5-LOX-IN-3 (compound 5b) (p.o.; male Sprague Dawley rats) shows anti-inflammatory activities in vivo[1]. Animal Model: Male Sprague Dawley rats[1] Dosage: 2.622 X 10-5 mol/kg Administration: Oral administration Result: The percentage inhibition of edema (%I) reached 58.77% after 4h.

[References]

[1]. Qandeel NA, et al. Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives. Bioorg Chem. 2020 Sep;102:103890.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H16ClN3O2S

[ Molecular Weight ]:
361.85

Related Compounds