sEH/AChE-IN-3

Names

[ CAS No. ]:
2490589-11-0

[ Name ]:
sEH/AChE-IN-3

Biological Activity

[Description]:

sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

IC50: 0.4 nM (hsEH), 1.94 ± 0.67 nM (hAChE), 615 ± 34 nM (hBChE), 4.3 nM (msEH), 2.61 ± 0.16 nM (mAChE)[1]


[References]

[1]. Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H39ClF3N5O3

[ Molecular Weight ]:
670.16

Related Compounds