LANA-DNA-IN-1

Names

[ CAS No. ]:
2512847-06-0

[ Name ]:
LANA-DNA-IN-1

Biological Activity

[Description]:

LANA-DNA-IN-1 is a potent LANA-DNA inhibitor. LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM. LANA-DNA-IN-1shows against wild-type LANA with IC50 value of 53 μM. LANA-DNA-IN-1 can be used for the research of infection[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[Target]

IC50: 8 μM (LBS2); 9μM LBS1); 8 μM (LBS3); 53 μM (wild-type LANA)[1]


[In Vitro]

LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM in FP Assay[1]. LANA-DNA-IN-1 has potent LANA-LBS1-inhibitory with an IC50 values of 53 μM[1]. LANA-DNA-IN-1 (31.25, 62.5, 125 and 250 μM) has potent against wild-type LANA CTD and the oligomerization-deficient LANA DBD mutant[1].

[References]

[1]. Philine Kirsch, et al. Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections. Eur J Med Chem. 2020 Sep 15;202:112525

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14N4O2

[ Molecular Weight ]:
330.34

Related Compounds