VEGFR-2-IN-21

Names

[ CAS No. ]:
2531029-88-4

[ Name ]:
VEGFR-2-IN-21

Biological Activity

[Description]:

VEGFR-2-IN-21 (Compound 5d) is a potent VEGFR-2 inhibitor with an IC50 of 0.10 μM. VEGFR-2-IN-21 shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR-2:0.10 μM (IC50)


[In Vitro]

VEGFR-2-IN-21 (Compound 5d) shows inhibitory activities against the three HepG2, HCT116 and MCF-7 cancer cell lines with IC50 values of 8.98 ± 0.1, 7.77 ± 0.1 and 6.99 ± 0.1 µM respectively[1].

[References]

[1]. Saleh NM, et al. Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors. Bioorg Chem. 2020 Nov;104:104350.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H24ClN7O3S

[ Molecular Weight ]:
574.05

Related Compounds