HIV-1 inhibitor-21

Names

[ CAS No. ]:
2554620-04-9

[ Name ]:
HIV-1 inhibitor-21

Biological Activity

[Description]:

HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1 (WT):12.7 nM (EC50)

HIV-1 (K103N):10.4 nM (EC50)


[References]

[1]. Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H24N6O2

[ Molecular Weight ]:
476.53

Related Compounds