Antimicrobial agent-1

Names

[ CAS No. ]:
2579696-45-8

[ Name ]:
Antimicrobial agent-1

Biological Activity

[Description]:

Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128 μg/mL in Caco-2 and Vero cell lines[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 2 μg/mL (TolC mutant E. coli)[1]


[References]

[1]. Dokla EME, et al. Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. Eur J Med Chem. 2020;186:111850.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H21N3O2S

[ Molecular Weight ]:
391.49

Related Compounds