7β-Hydroxy-epi-androsterone
Names
[ CAS No. ]:
25848-69-5
[ Name ]:
7β-Hydroxy-epi-androsterone
Biological Activity
[Description]:
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone[1][2][3].
[Related Catalog]:
[Target]
ERβ
[In Vitro]
7β-Hydroxy-epi-androsterone (1、10 和 100 nM,72 小时) 在 E2 (10 nM) 存在的情况下抑制 MCF-7 和 MDA-MB-231 细胞增殖[2]。 7β-Hydroxy-epi-androsterone (1、10 和 100 nM,48 小时) 导致 MCF-7 和 MDA-MB-231 细胞的 G0/G1 细胞周期停滞[2]。 7β-Hydroxy-epi-androsterone (1、10 和 100 nM,48 小时) 在 E2 (10 nM) 存在的情况下增加 MCF-7 细胞的细胞凋亡[2]。 7β-Hydroxy-epi-androsterone (1、10 和 100 nM,24 小时) 与 ERβ 结合并降低 MDA-MB-231 细胞中的反式激活[2]。 Apoptosis Analysis[2] Cell Line: MCF-7 cells Concentration: 1, 10 and 100 nM (in presence of 10 nM E2) Incubation Time: 48 h Result: Increased cell apoptosis in presence of E2.
[In Vivo]
7β-Hydroxy-epi-androsterone (i.p.,每天一次,连续 7 天) 对 DSS 诱导的结肠炎大鼠显示出抗炎作用[3]。 7β-Hydroxy-epi-androsterone (0.1 mg/kg 皮下注射,每日两次,持续 10 天) 对阿尔茨海默病大鼠的炎症性神经变性和神经胶质细胞死亡展现出保护作用[4]。 Animal Model: Rat with DSS-induced colitis[3] Dosage: 0.01, 0.1 and 1 mg/kg Administration: Intraperitoneal injection (i.p.), once a day for 7 days. Result: Increased in COX-2 and PGE synthase expression. Increased colonic tissue levels of 15d-PGJ2 levels.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H30O3
[ Molecular Weight ]:
306.44