RBP4 ligand-1

Names

[ CAS No. ]:
260553-24-0

[ Name ]:
RBP4 ligand-1

Biological Activity

[Description]:

RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4–TTR FRET IC50 values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Retinol-Binding Protein 4 (RBP4) is a physiological carrier of retinol (vitamin A) in blood, delivering retinol from the liver to peripheral tissues.RBP4 ligand-1 has the ability to disrupt the RBP4–TTR protein–protein interaction (hRPB4–TTR). The RBP4–TTR FRET IC50 is 0.13±0.12 μM in FRET assay[1].

[In Vivo]

RBP4配体

[References]

[1]. Yingcai Wang, et al. Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2885-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H18ClF3N4O2

[ Molecular Weight ]:
414.81

Related Compounds